Schwarz conceived the series in 2000, when he was running Rumpus toys, a toy design company in New York City, but they folded before any storyboarding could commence. They resurfaced years later as Animation Collective, and produced an early test pilot for a pitch to MTV Networks, where the character designs and backgrounds resembled more like those found in Adult Swim series Perfect Hair Forever, and the humor was also more adult-oriented. Much of the current cast was voicing their characters even this early in production. MTV declined the deal, and Nickelodeon eventually picked up the project. The series was tweaked heavily in order to be aimed at a younger audience. Voice talents were usually local, and its audio was recorded at Manhattan-based NYAV Post, which Michael Sinterniklaas owns. Larry Schwarz, along with the other executive producers, oversaw all phases of production, but only had writing credits on the pilot episode, “Mikey Impossible” and “A Christmas Mikey”. All the episodes were directed by Sergei Aniskov. The instrumental score was composed by John Angier, who also wrote the lyrics to “The Recycling Song”, “Ori and Yori’s Hits”, “Living With Mikey”, “How Did We Get Here?” and the songs from “The Karaoke Episode”.